Sodium Hyaluronate/Hyaluronic Acid/CAS 9004-61-9 Food Grade,Cosmetic Grade,Eye Drops Grade,Medical Grade,Injection Grade

---Product Description---

1.Sodium hyaluronate itself is a component of human skin. It is an acidic mucosity sugar widely distributed in the human body. It exists in the matrix of connective tissue and has a good moisturizing effect. It is known as an ideal natural moisturizing factor internationally. It is the substance with the best moisturizing performance in cosmetics currently found in nature.

2.Sodium hyaluronate (HA for short) is a mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid disaccharide repeating units. Commercial HA is usually in the form of its sodium salt, called sodium hyaluronate. HA is widely present in the interstitial cells of animal tissues and the vitreous body of the eye. Its main physiological function is water retention and lubrication. 75% of the fluid in the human eye is hyaluronic acid.

3.Production process:Biosynthesis:

1）The production process uses semi-fermented products for synthesis, mainly used for low molecular weight specifications

2）Biofermentation: The product obtained by fermenting microorganisms and raw materials, with simple process, low production cost and wide use.

3）Enzyme cutting: Biological enzymes cut the molecular chain to obtain small molecule products, mainly used for low molecular weight specifications.  

---Product classification and Application---

Hyaluronic acid can be divided into food grade, cosmetic grade and pharmaceutical grade

1.Food grade

1）Benefits of consuming sodium hyaluronate:
Oral sodium hyaluronate can increase the content of hyaluronic acid in the body after digestion and absorption. Long-term use can increase the prerequisite substances for the synthesis of sodium hyaluronate in the body, promote the production of HA, effectively improve skin moisture, delay aging, improve joints and other effects

2）Application of food-grade sodium hyaluronate:
HA is used in health foods and is often used in combination with collagen, vitamins, chondroitin sulfate, glucosamine and other ingredients. Tablets, capsules, and oral liquids are commonly used dosage forms. On January 7, 2021, the National Health Commission issued an official announcement approving sodium hyaluronate (ie hyaluronic acid, HA) as a new food raw material, which can be used in ordinary food additions. The scope of use is milk and dairy products: 0.2g/kg, beverages (liquid beverages ≤50mL packaging: 2.0g/kg, 51mL-500ml packaging: 0.2g/kg. Solid beverages are converted according to the liquid volume after mixing), wine (1.0g/kg), cocoa products, chocolate and chocolate products (including cocoa butter substitute chocolate and products) and candy (3.0g/kg), frozen drinks (2.0g/kg). It is not suitable for consumption by infants, pregnant women and lactating women. The label and instructions should indicate the unsuitable population, and the recommended consumption should be < 200mg per day.

As we age, cell metabolism slows down, and the body's ability to synthesize hyaluronic acid gradually decreases. On the one hand, the collagen fibers and elastic fibers in the skin do not get enough water, causing the skin to lose elasticity and wrinkles. On the other hand, the reduction of hyaluronic acid in the synovial fluid weakens the protective effect of shock absorption and lubrication on the joint cartilage, which will lead to joint pain, limited movement and other joint inflammation.

The synthesis and decomposition of hyaluronic acid in the human body is a dynamic equilibrium process. Animal and human experiments have shown that oral hyaluronic acid can directly supplement the missing hyaluronic acid in the body, and can increase the precursor substances for synthesizing hyaluronic acid in the body, promoting the synthesis of hyaluronic acid.

2.Cosmetic grade

As an internationally recognized natural moisturizing factor, hyaluronic acid can be used in creams, lotions, toners, essences, facial masks, cleansers, makeup and other cosmetics. Depending on the amount of HA added and the molecular weight, the characteristics of the cosmetics are also different.

Sodium hyaluronate has a strong water absorption capacity and can absorb 1000 times its own volume of water to form an elastic viscous matrix to fill the gaps in the tissue. It is a natural water retainer for the skin. In addition, it also has skin nutrition and repair effects.

1）Acetylated Sodium Hyaluronate: Acetylated Sodium Hyaluronate (AcHA) is a derivative of sodium hyaluronate (HA), which is derived from sodium hyaluronate (HA) through acetylation reaction. It has both hydrophilicity and lipophilicity. It can double moisturize, repair the stratum corneum barrier, and improve skin elasticity. It can improve dry and rough skin and make the skin soft and elastic.

Application of acetylated sodium hyaluronate in cosmetics:
Moisturizing and skin care
Prevention and repair of skin cell damage, nourishing the skin and delaying skin aging
Good lubricant and smooth skin feel
Thickening and stabilizing emulsification

2）Hydrolyzed Sodium Hyaluronate: Sodium hyaluronate commonly used in cosmetics has a relatively large molecular weight structure. When applied externally to the skin, it is not easy to absorb and basically stays on the stratum corneum. Therefore, the high molecular weight sodium hyaluronate is degraded by biological enzymes to obtain sodium hyaluronate with a smaller molecular weight, which is called "hydrolyzed sodium hyaluronate".

Product application:
It can be widely used in cosmetics, such as essence, lotion, mask, eye cream, sunscreen, spray, etc.

Product features:
The hydrolyzed sodium hyaluronate obtained by enzymatic hydrolysis has better biological activity and better permeability than medium-molecule macromolecules. It can penetrate the stratum corneum and enter below the stratum corneum to quickly replenish nutrients to cells. It can be quickly absorbed through the skin, repair damaged cells, improve cell activity, increase the water content of the skin, fully lock in moisture, improve dry skin and dehydration, delay skin aging, have a beauty effect, and can also promote wound healing.

3）Acetated sodium hyaluronate: It can replenish nutrients in the skin and reduce the formation of wrinkles. It allows sodium hyaluronate to break through the field of traditional moisturizing ingredients and become a truly effective moisturizing and anti-aging ingredient. It can make the skin hydrated, bright and eliminate dullness. It is widely used in high-end skin care products.

Compared with traditional sodium hyaluronate:
Better skin feel: Esterified sodium hyaluronate cosmetics feel very refreshing and smooth. It overcomes the shortcomings of traditional sodium hyaluronate, such as poor permeability, easy degradation and strong viscosity. It has no skin irritation, no cytotoxicity, good adhesion and moisturizing properties on the skin surface. It is currently the best sodium hyaluronate derivative for repairing skin trauma and delaying skin aging.
Stronger permeability: Esterified sodium hyaluronate has a small molecular weight, good permeability, and stronger affinity with the skin, which has a super hydrating and water-locking effect.
Esterified sodium hyaluronate has strong repair ability and anti-wrinkle effect: In addition to the strong moisturizing effect of traditional sodium hyaluronate, the nutrients it contains are also the structural stabilizing elements of collagen and elastin in the skin, which can make the skin produce more fibroblasts and promote the synthesis of collagen.

3.Pharmaceutical grade

1）Eye drop grade sodium hyaluronate
Can be used for eye drops, contact lens solutions, topical preparations for wound or burn healing, medical lubricants, lubrication, moisturizing, improving drug efficacy, relieving dry eye, promoting healing of corneal and conjunctival injuries, wound healing, drug or cell carriers/matrix, repairing damaged mucosa or cartilage, etc.

Advantages of Shengheyuan eye drops grade sodium hyaluronate.First: Lower endotoxins:The European Pharmacopoeia standard for eye drops of sodium hyaluronate is bacterial endotoxin < 0.5lU/mg. Second: Lower protein content:The European Pharmacopoeia standard for eye drops of sodium hyaluronate is protein content < 0.1%

2）Injectable grade sodium hyaluronate: commonly used in non-intestinal preparations, including intra-articular and intraocular preparations, such as OVD, intra-articular injections, intradermal cosmetic correctors, wrinkle filling, medical micro-surgery, anti-adhesion products, etc. Lubrication, viscoelasticity, repair of damaged cartilage, inhibition of inflammation, pain relief, etc. Hydroxyapatite and its derivatives have good biocompatibility and degradability.

Advantages of Runxin Injectable Sodium Hyaluronate.First: Lower endotoxin: The European Pharmacopoeia standard for injectable sodium hyaluronate is bacterial endotoxin < 0.05lU/mg. Second: Lower protein content: The European Pharmacopoeia standard for injectable sodium hyaluronate is protein content < 0.1%

3）Cross-linked sodium hyaluronate：

Function:
First: Face shaping
Hyaluronic acid gel can effectively shape the face, a high nose bridge, sexy lips, perfect face shape...Upgrade your appearance, just one shot, you can achieve the "gold standard" face shape, no surgery, make the effect more lasting, shape more three-dimensional.
Scope: Rhinoplasty, lip augmentation, temple augmentation, cheek augmentation, earlobe augmentation, forehead augmentation, overall face shape adjustment, breast augmentation, hip augmentation, chin augmentation...

Second: Locking water and moisturizing
Hyaluronic acid exists in large quantities in the deep layer of the skin, and the content is highest in the skin of young babies. Hyaluronic acid can absorb 500cc of water, so that the skin is no longer "thirsty". After absorbing water, hyaluronic acid will keep the elastic fibers and collagen in the skin in a moist environment for a long time, making the skin instantly more hydrated and elastic.
Scope: The whole face

Third: Powerful wrinkle removal
Can smooth out large and small wrinkles. After injecting hyaluronic acid, the skin surface is restored to a plump state, wrinkles are instantly smoothed, and people immediately have youthful and natural beauty.
Range: forehead horizontal lines, vertical lines between eyebrows, dimple lines, nasolabial grooves, lip wrinkles, nose root horizontal lines, facial wrinkles, wrinkles before ears, neck horizontal lines... all can be easily fixed

---Certificate of Analysis-Hyaluronic Acid Dermal Filler---